E. Coli Engineered to Diagnose Inflammatory Bowel Disease
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May 17, 2021
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Rice University researchers say they have engineered a bacterium with the necessary capabilities for diagnosing a human disease. The engineered strain of the gut bacteria
E. coli senses pH and glows when it encounters acidosis, an acidic condition that often occurs during flareups of inflammatory bowel diseases like colitis, ileitis, and Crohn’s disease, according to the scientists.
Researchers at the University of Colorado (CU) School of Medicine used the Rice-created organism in a mouse model of Crohn’s disease to show acidosis activates a signature set of genes. The corresponding genetic signature in humans has previously been observed during active inflammation in Crohn’s disease patients. The study (“Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation”) is availa
A MAN has been jailed after slashing another man’s neck with a cut throat razor. Alex Lapinski launched an unprovoked attack on his victim in the toilets of a Lancashire hotel in January last year. The victim, a 57-year-old man from Morecambe, suffered a 10-centimetre cut to the neck and was lucky to survive the injury. Police were called to The Pier Hotel in Morecambe, and Lapinki was quickly arrested. He was charged the next day. Following a trial, Lapinki, 57, of Aberdeen Road, Lancaster, was convicted of attempted murder. At Preston Crown Court on Friday, he was jailed for 12 years and will be subject to a life licence on his release.
Morecambe cut-throat razor attack: Alexander Lapinski jailed
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image captionAlexander Lapinski denied attempted murder but was convicted by jury
A man who used a cut-throat razor to slash a man s neck in a horrific and unprovoked attack has been jailed for attempted murder.
Alexander Lapinski, 58, from Lancaster, Lancashire attacked his victim in the toilets of the Pier Hotel pub in Morecambe in January last year.
His 57-year-old victim suffered a four-inch (10cm) slash wound and was lucky to survive , Lancashire Police said.
Lapinski, who pleaded not guilty, was given a 12-year jail term.
Following a trial at Preston Crown Court, Lapinski, of Aberdeen Road, was convicted of attempted murder and possession of a bladed article.
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