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Bioengineers create pH-sensing gut bacteria to diagnose inflammatory bowel disease Researchers engineered a strain of the gut bacteria E. coli to detect gastrointestinal acidosis. May 25, 2021 In an important step toward the clinical application of synthetic biology, Rice University researchers have engineered a bacterium with the capability of diagnosing a human disease. An engineered strain of the gut bacteria E. coli senses pH and glows when it encounters acidosis, an acidic condition that often occurs during flareups of inflammatory bowel diseases like colitis, ileitis and Crohn s disease. The pH-sensing circuit was discovered by Rice researcher Kathryn Brink. Researchers at the University of Colorado then used the Rice-created organism in a mouse model of Crohn s disease to show that acidosis activates a signature set of genes. The corresponding genetic signature in humans has been observed during active inflammation in Crohn s disease patients. The U.S. National Science

United statesIan cartwrightDavid rockcliffeSean colganJeffrey taborDivision of molecularResearch newsUniversity of coloradoProceedings of the national academy sciencesUs national scienceRice universityScience foundation fundedNational academyCellular biosciencesNational science foundationஒன்றுபட்டது மாநிலங்களில்