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First patient-derived organoid model for cervical cancer

First patient-derived organoid model for cervical cancer
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Crying human tear glands grown in the lab

Credit: Marie Bannier-Hélaouët, copyright Hubrecht Institute Researchers from the lab of Hans Clevers (Hubrecht Institute) and the UMC Utrecht used organoid technology to grow miniature human tear glands that actually cry. The organoids serve as a model to study how certain cells in the human tear gland produce tears or fail to do so. Scientists everywhere can use the model to identify new treatment options for patients with tear gland disorders, such as dry eye disease. Hopefully in the future, the organoids can even be transplanted into patients with non-functioning tear glands. The results will be published in

Researchers grow crying human tear glands in the lab

Scientists have grown miniature human tear glands capable of crying. Researchers say the organoids serve as a model to study how certain cells in the human tear gland produce tears or fail to do so. They hope it may become possible to transplant the lab-grown glands into patients with non-functioning tear glands. The tear gland is in the upper part of the eye socket, and secretes tear fluid which is essential for lubrication and nutrition of the cornea and has antibacterial components. Ophthalmologist and researcher on the project, Rachel Kalmann, from UMC Utrecht in the Netherlands, said: “Dysfunction of the tear gland, for example in Sjogren’s syndrome, can have serious consequences including dryness of the eye or even ulceration of the cornea.

Researchers grow crying human tear glands in the lab

Researchers grow crying human tear glands in the lab
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Researchers grow crying human tear glands in the lab

Researchers grow crying human tear glands in the lab
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