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Novartis presents pivotal Phase III APPLY-PNH data at ASH demonstrating investigational oral monotherapy iptacopan superiority over anti-C5

Novartis presents pivotal Phase III APPLY-PNH data at ASH demonstrating investigational oral monotherapy iptacopan superiority over anti-C5
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United statesFrance generalGiuseppe moscatiDavid soergelMichael meoPrnewswire novartisJulie masowSloan simpsonAnn hematolMary carmichaelAntonio risitanoNovartis institutes for biomedical researchInterest groupExchange commissionGreater paris university hospitalNovartis pharmaceuticals

What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients?

Researchers examined the prevalence of contraindications to nirmatrelvir-ritonavir (Paxlovid) in hospitalized coronavirus disease 2019 (COVID-19) patients.

France generalUnited statesAimee molineuxNeha mathurnovNeha mathurDrug administrationGreater paris universityImage creditUnited states foodParis universityStrengthening the reportingObservational studiesLassistance publiqueCoronavirus disease covid 19Covid 19

Study uncovers blood clotting and immune protein pathways impacted in children with severe COVID-19

Researchers have discovered the blood clotting and immune protein pathways that are activated in severe cases of COVID-19 in children, paving the way for earlier diagnosis and more targeted treatments.

France generalNew south walesVera ignjatovicEnfants maladesNecker enfants maladesDamien bonnetConor mccaffertyEmily hendersonNature communicationsUniversity of melbourne phUniversity of melbourneMurdoch children research instituteGreater paris university hospitalsMurdoch childrenResearch instituteMelbourne phd

Scientists discover pathways to severe Covid in kids

Scientists discover pathways to severe Covid in kids
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France generalNew south walesSylvain renolleauChantal attardSlavica praporskiJemma wuMeryl vedrenne cloquetNatasha letunicaPaul monagleTengyi caiDominique lasneVera ignjatovicNecker enfants maladesThiri zawEnfants maladesDamien bonnet

Phase II trial to establish if alisporivir can prevent COVID-19 progression

The trial will assess whether alisporivir (Debio 025) can significantly reduce COVID-19 viral load in hospitalised COVID-19 patients.

France generalBertrand ducreyJean michel pawlotskyPathology departmentGreater paris university hospitalsHenri mondor hospital groupAcute respiratory distress syndromeHenri mondor hospitalProfessor jean michel pawlotskyGreater paris universityChief executive officerபிரான்ஸ் ஜநரல்நோயியல் துறைஅதிகமானது பாரிஸ் பல்கலைக்கழகம் மருத்துவமனைகள்ஹென்றி மோந்டோர் மருத்துவமனை குழுஎடுப்போசை சுவாச துன்பம் நோய்க்குறி