Including data from people of diverse ancestries substantially improves certain genetic risk predictions in all populations, according to a study that examined the genes responsible for regulating blood cholesterol levels.
Daily Express is the sister paper of Overseas Chinese Daily News (OCDN). It was founded by the late Tan Sri Yeh Pao Tzu and the first issue hit the streets on March 1, 1963. Published in trilingual ie English, Bahasa Malaysia and Kadazan, it is by far the largest circulation daily newspaper in Sabah.
A genome-wide association study (GWAS) on 120 primary studies including 1.65 million participants including nearly 350,000 participants from non-European ancestries, shows including participants of diverse ancestries facilitates the identification of genomic variants that are more strongly associated with cardiovascular diseases. The authors noted, trans-ancestry GWAS will help identify effector genes and allow for accelerated biological insight and identification of potential drug targets.
In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.