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Diverse Genome Sequences Provide a Powerful Tool for Studying Risk of Heart Disease

Genome study unlocks risk of heart disease | Daily Express Online - Sabah s Leading News Portal

Daily Express is the sister paper of Overseas Chinese Daily News (OCDN). It was founded by the late Tan Sri Yeh Pao Tzu and the first issue hit the streets on March 1, 1963. Published in trilingual ie English, Bahasa Malaysia and Kadazan, it is by far the largest circulation daily newspaper in Sabah.

Diverse Ancestries Yield More Predictive Genetic Risk Scores for Heart Disease

A genome-wide association study (GWAS) on 120 primary studies including 1.65 million participants including nearly 350,000 participants from non-European ancestries, shows including participants of diverse ancestries facilitates the identification of genomic variants that are more strongly associated with cardiovascular diseases. The authors noted, trans-ancestry GWAS will help identify effector genes and allow for accelerated biological insight and identification of potential drug targets.

Diverse genome sequences provide a powerful tool for studying risk of heart disease

In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.

Diverse genome sequences generate a polygenic risk score to predict heart disease risk

In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.

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