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The typical lag between treatment initiation with SSRIs for depression and enhanced mood may be because of the time it takes to increase brain synaptic density, new imaging data suggest.

Comunidad autonoma de catalunaCity ofUnited kingdomDavid nuttOliver howesGitta moos knudsenEuropean college of neuropsychopharmacologySwedish research councilLundbeck foundationRoyal libraryDepartment of clinical medicineCopenhagen university hospitalKing college londonCopenhagen university libraryDanish council for independent researchSensory sciences