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Researchers develop universal MHC molecules that can be produced rapidly at scale

Class I major histocompatibility complex (MHC-I) proteins play an essential role in the immune system of all jawed vertebrates. The MHC-I displays peptide fragments of proteins from within the cell on the cell surface, "presenting" them to the immune system, which is constantly scanning the body for foreign or toxic antigens.

University of pennsylvaniaUnited statesGeorge burslemMichaelc youngClaireh woodwardNikolaosg sgourakisYi sunSgourakis labProceedings of the national academy sciencesNational academyAssociate professorGenomic medicine

CHOP Researchers Develop Universal MHC Molecules that Can be Produced Rapidly at Scale

/PRNewswire/ Class I major histocompatibility complex (MHC-I) proteins play an essential role in the immune system of all jawed vertebrates. The MHC-I.

United statesUniversity of pennsylvaniaFox chase cancer centerNew jerseyMichaelc youngClaireh woodwardGeorge burslemNikolaosg sgourakisYi sunSgourakis labCare networkProceedings of the national academy sciencesNational academyAssociate professorGenomic medicine

CHOP Researchers Develop Universal MHC Molecules that Can be Produced Rapidly at Scale

The molecules open the door for development of immunotherapies that are truly universal and work across HLA types, regardless of patient ancestr.

University of pennsylvaniaUnited statesFox chase cancer centerNew jerseyNikolaosg sgourakisClaireh woodwardGeorge burslemYi sunMichaelc youngSgourakis labProceedings of the national academy sciencesCare networkNational academyAssociate professorGenomic medicine

Eight Penn Medical School researchers win High-Risk, High-Reward grants from the NIH

Eight Penn Medical School researchers win High-Risk, High-Reward grants from the NIH
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United statesNina dilworthDonita bradyLuca businoTerence gadeChengcheng jinSophia leungEric witzeGeorge burslemAmelia escolanoBushra rajNational institute of healthUpenn medical schoolPerelman school of medicineTransformative research awardNational institute of health high