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CHOP researchers unlock 3D structure of crucial protein for cancer therapy

Chimeric Antigen Receptors (CARs) have opened up an exciting new field of therapeutic advancements for rare and difficult-to-treat cancers, as they have the ability to deliver targeted therapies that can kill tumor cells.

United statesUniversity of pennsylvaniaUnited kingdomNikolaosg sgourakisJohnm marisNational cancer instituteMark foundationAmerican association for cancer researchEntertainment industry foundationBaldrick foundationSgourakis labC dream team translational research grantNeuroblastoma researchPhiladelphia science centerCancer research united kingdomScience center quod erat demonstrandum

CHOP Researchers Enhance CAR Therapy with Deep Biology Links

CHOP Researchers Enhance CAR Therapy with Deep Biology Links
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United statesNew jerseyUniversity of pennsylvaniaUnited kingdomNikolaosg sgourakisJohnm marisEntertainment industry foundationNeuroblastoma researchMark foundationCancer research united kingdomCare networkC dream team translational research grantSgourakis labScience center quod erat demonstrandumNational cancer instituteBeau biden cancer moonshot program

Researchers discover deep structural biology connections that help improve CAR therapy

Researchers discover deep structural biology connections that help improve CAR therapy
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University of pennsylvaniaUnited statesJohnm marisNikolaosg sgourakisNikolaos sgourakisNeuroblastoma researchSgourakis labAssociate professorGenomic medicineGiuliod angio chair

Deep Structural Biology Links Boost CAR Therapy: Study

Deep Structural Biology Links Boost CAR Therapy: Study
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University of pennsylvaniaUnited statesUnited kingdomJohn marisNikolaosg sgourakisJohnm marisNikolaos sgourakisAmarachi onwukaCancer research united kingdomC dream team translational research grantBeau biden cancer moonshot programPhiladelphia science centerNational cancer instituteSgourakis labAmerican association for cancer researchBaldrick foundation

CHOP researchers engineer stable, universal MHC-I molecules in a shorter timeframe

Class I major histocompatibility complex (MHC-I) proteins play an essential role in the immune system of all jawed vertebrates. The MHC-I displays peptide fragments of proteins from within the cell on the cell surface, "presenting" them to the immune system, which is constantly scanning the body for foreign or toxic antigens.

University of pennsylvaniaUnited statesFox chase cancer centerMichaelc youngGeorge burslemLily ramseyNikolaosg sgourakisYi sunClaireh woodwardSgourakis labProceedings of the national academy sciencesNational academySenior authorAssociate professorGenomic medicineImmune response