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Intensified screening for SARS-CoV-2 in 18 emergency departments in the Paris metropolitan area, France (DEPIST-COVID): A cluster-randomized, two-period, crossover trial

Judith Leblanc and co-workers report a cluster-randomized trial evaluating intensive screening for SARS-CoV-2 infection in emergency departments.

France generalÎe de franceNorth carolinaUnited statesRenaud piarrouxFatiha djennaouiMohamed hamidoucheSonia laridInfectieuses emergentesMartine piarrouxNational research priorityFrench ministry of healthNational orientation committee for therapeutic trialsCommittee for patient protectionClinical research center parisAblative solutions

Genetic risk converges on regulatory networks mediating early type 2 diabetes

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is characterized by dysfunction of insulin-producing pancreatic islet β cells1,2. T2D genome-wide association studies (GWAS) have identified hundreds of signals in non-coding and β cell regulatory genomic regions, but deciphering their biological mechanisms remains challenging3–5. Here, to identify early disease-driving events, we performed traditional and multiplexed pancreatic tissue imaging, sorted-islet cell transcriptomics and islet functional analysis of early-stage T2D and control donors. By integrating diverse modalities, we show that early-stage T2D is characterized by β cell-intrinsic defects that can be proportioned into gene regulatory modules with enrichment in signals of genetic risk. After identifying the β cell hub gene and transcription factor RFX6 within one such module, we demonstrated multiple layers of genetic risk that converge on an RFX6

Robertc turnerArrojoe drigoFoundation for statistical computingHuman pancreas analysis programIslet distribution programInternational diabetes federation atlasRr core teamHaplotype reference consortiumHuman pancreas analysisCell metabIntegrated islet distribution programApplied longitudinal analysisGene ontologyAcids resCell proteomicsGenome biol

Burden of diarrhea and antibiotic use among children in low-resource settings preventable by Shigella vaccination: A simulation study

Leveraging data from 1715 children in the MAL-ED birth cohort study, Stephanie A Brennhofer and colleagues model the expected reduction in diarrhea episodes, antibiotic use, and bystander pathogen exposure to antibiotics through the administration of Shigella vaccines.

Monte carloNepal generalUnited statesTamil naduMinas geraisSouth africaNaushero ferozeNational institute for medical researchHealth ministryChristian medical collegeFogarty international centerEmory university atlantaMelinda gates foundationThermo fisherNational ethical research committeeIndian council of medical research india

SciELO - Brasil - Benthic Macroinvertebrates Associated with Riparian Habitat Structural Diversity in an Eastern Amazon Stream Urbanization Gradient Benthic Macroinvertebrates Associated with Riparian Habitat Structural Diversity in an Eastern Amazon Stream Urbanization Gradient

SciELO - Brasil - Benthic Macroinvertebrates Associated with Riparian Habitat Structural Diversity in an Eastern Amazon Stream Urbanization Gradient Benthic Macroinvertebrates Associated with Riparian Habitat Structural Diversity in an Eastern Amazon Stream Urbanization Gradient
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Estado de mato grossoMinas geraisSanta catarinaUnited kingdomRio de janeiroEstado do rioUnited statesRio grandeRio grande do sulAlto uruguaiPonta grossaGrand duchy of luxembourgHydropsychidae trichopteraPerspectiva erechimElmidae coleopteraKaufmannv caracteriza

Effect of breathwork on stress and mental health: A meta-analysis of randomised-controlled trials

Deliberate control of the breath (breathwork) has recently received an unprecedented surge in public interest and breathing techniques have therapeutic potential to improve mental health. Our meta-analysis primarily aimed to evaluate the efficacy of breathwork through examining whether, and to what extent, breathwork interventions were associated with lower levels of self-reported/subjective stress compared to non-breathwork controls. We searched PsycInfo, PubMed, ProQuest, Scopus, Web of Science, ClinicalTrials.gov and ISRCTN up to February 2022, initially identifying 1325 results. The primary outcome self-reported/subjective stress included 12 randomised-controlled trials (k = 12) with a total of 785 adult participants. Most studies were deemed as being at moderate risk of bias. The random-effects analysis yielded a significant small-to-medium mean effect size, g = − 0.35 [95% CI − 0.55, − 0.14], z = 3.3

New yorkUnited statesUnited kingdomRepublic ofIndianj palliatSudarshan kriyaErol ursavasPaul josephRd claude bernardCleve clinRajendra acharyaRobert wood johnson foundationWorld health organisationDevelopment of the perceived stress questionnaireWe need to talk campaignNutrients yoga in mental health care