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New multi-task deep learning framework integrates large-scale single-cell proteomics and transcriptomics data

New multi-task deep learning framework integrates large-scale single-cell proteomics and transcriptomics data
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Jing xuAdvanced scienceWuhan botanical gardenChinese academyFormer integrates largeScale singleCell proteomicsTranscriptomics dataTask transformer

Necroptosis blockade prevents lung injury in severe influenza

Severe influenza A virus (IAV) infections can result in hyper-inflammation, lung injury and acute respiratory distress syndrome1–5 (ARDS), for which there are no effective pharmacological therapies. Necroptosis is an attractive entry point for therapeutic intervention in ARDS and related inflammatory conditions because it drives pathogenic lung inflammation and lethality during severe IAV infection6–8 and can potentially be targeted by receptor interacting protein kinase 3 (RIPK3) inhibitors. Here we show that a newly developed RIPK3 inhibitor, UH15-38, potently and selectively blocked IAV-triggered necroptosis in alveolar epithelial cells in vivo. UH15-38 ameliorated lung inflammation and prevented mortality following infection with laboratory-adapted and pandemic strains of IAV, without compromising antiviral adaptive immune responses or impeding viral clearance. UH15-38 displayed robust therapeutic efficacy even when administered late in the course of infection, suggesti

United statesAmerican thoracic societyScare medHost microbeMicrobes infectTissue resDeath disCell proteomicsCancer resCell physiolDeath differ

Genetic risk converges on regulatory networks mediating early type 2 diabetes

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is characterized by dysfunction of insulin-producing pancreatic islet β cells1,2. T2D genome-wide association studies (GWAS) have identified hundreds of signals in non-coding and β cell regulatory genomic regions, but deciphering their biological mechanisms remains challenging3–5. Here, to identify early disease-driving events, we performed traditional and multiplexed pancreatic tissue imaging, sorted-islet cell transcriptomics and islet functional analysis of early-stage T2D and control donors. By integrating diverse modalities, we show that early-stage T2D is characterized by β cell-intrinsic defects that can be proportioned into gene regulatory modules with enrichment in signals of genetic risk. After identifying the β cell hub gene and transcription factor RFX6 within one such module, we demonstrated multiple layers of genetic risk that converge on an RFX6

Robertc turnerArrojoe drigoFoundation for statistical computingHuman pancreas analysis programIslet distribution programInternational diabetes federation atlasRr core teamHaplotype reference consortiumHuman pancreas analysisCell metabIntegrated islet distribution programApplied longitudinal analysisGene ontologyAcids resCell proteomicsGenome biol

Research and Markets: Europe Single Cell Multiomics Market Report 2022: Sector to Grow by 18% Annually Through 2031

The "Europe Single Cell Multiomics Market 2021-2031 by Product Type, Omics Type, Application, Sample Type, Workflow, End User, and Country: Trend Forecast and Growth Opportunity" report has been added

Dennis riedlLaura woodNanostring technologies incBioturing incXcellbio incNamocell incDanaher corporation cytiva life sciencesOther types of clinical researchBiotech companiesTakara bio incGenomics co ltdGenomics incClinical researchShilps sciencesRarecyte incParse biosciences inc

North America Single Cell Multiomics Market 2022: Sector to Reach $6 15 Billion by 2031 at a 17 6% CAGR

/PRNewswire/ The "North America Single Cell Multiomics Market 2021-2031 by Product Type, Omics Type, Application, Sample Type, Workflow, End User, and.

United statesLaura woodNanostring technologies incBioturing incXcellbio incNamocell incDanaher corporation cytiva life sciencesOther types of clinical researchBiotech companiesTakara bio incGenomics co ltdGenomics incClinical researchShilps sciencesRarecyte incParse biosciences inc