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Key molecular mechanism disrupting human biological clocks found

It is known that molecular clocks in our cells synchronise our bodies with the cycle of night and day, cue us for sleep and waking, and drive daily cycles in virtually every aspect of our physiology.

Carrie partchUniversity of california santa cruzCalifornia santa cruzFamilial advanced sleep phase syndromeMolecular mechanism disrupting biological clocksEy event controlling clock timing in humansTudy on molecular interactions in sleep disorderAmilial advanced sleep phase syndrome fasp and clock timingEnetic mutation causing extreme morning larksIsrupted period protein interactions in faspHosphorylation and regulation of period proteinHortening of clock cycle in fasp mutationNhibition of kinase activity and clock lengtheningOtential drug targets for sleep related disorders

Genetic Mutation Behind FASP Syndrome Decoded

A study reveals important details of the molecular interactions that are disrupted in people with an inherited sleep disorder called FASP. 

Carrie partchJonathan philpottMolecular cellFamilial advanced sleep phase syndrome

New Study Uncovers Molecular Interaction Regulating Biological Clocks

New Study Uncovers Molecular Interaction Regulating Biological Clocks
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Alfred freebergSarvind tripathiYao caiDavid segalKwangjun leeAndrew mccammonCarrie partchRafael roblesJoanna chiuJonathan philpottRajesh narasimamurthyChoogon lee at florida state universityUs national institutes of healthSingapore ministry of healthMolecular cellFamilial advanced sleep phase syndrome
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