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Searching for Surrogates: The Effort to Speed Up Drug Trials

Identifying surrogate endpoints for use in clinical trials that strongly predict clinical outcomes such as improved survival and quality of life is challenging.

United statesNational institutes of healthSan franciscoAmaru kishanHiddol heerspinkVincent plancheJuliaa beaverCarol taylor burdsLos angelesKarin hoelzerFabio confortiRichard pazdurAnushka waliaEmersony chenGinny beakesFady ghali

Searching for Surrogates: The Effort to Speed Up Drug Trials

Identifying surrogate endpoints for use in clinical trials that strongly predict clinical outcomes such as improved survival and quality of life is challenging.

United statesNational institutes of healthSan franciscoFabio confortiVincent plancheFady ghaliKarin hoelzerGinny beakesCarol taylor burdsAmaru kishanRichard pazdurHiddol heerspinkAnushka waliaLos angelesEmersony chenJuliaa beaver

Is pCR a Reliable Survival Surrogate in Breast Cancer Trials?

Pathologic complete response (pCR) is not a reliable surrogate endpoint in neoadjuvant therapy trials for early breast cancer; alternatives are needed, researchers said.

Fabio confortiReuters healthEuropean institute of oncologyEuropean instituteHealthcare and medical technologyEalth and medical techEalth and med techEalth and medical technologyBreast cancerAlignant breast neoplasmClinical researchClinical trialsLinical studiesMeta analysis

Combo Therapy Shows Promise in Advanced Thymic Epithelial Tumors

'Clinically remarkable outcomes' with PD-L1 inhibitor plus anti-angiogenesis agent

United statesSoichiro funakiYasushi shintaniMike bassettFabio confortiEuropean institute of oncologyOsaka university graduate school of medicineEuropean instituteOsaka university graduate school

Pathological Complete Response Likely Not a Reliable Survival Surrogate in Early Breast Cancer

Pathological Complete Response Likely Not a Reliable Survival Surrogate in Early Breast Cancer
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Fabio confortiReuters healthDrug administrationInstitute of oncologyGallen international breast cancer consensus conference

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