PhD Candidate in Environmental Seismology for Detection of Rockslide Activity in Norway in Geology, Environmental, Earth & Marine Sciences, Academic Posts with NORWEGIAN UNIVERSITY OF SCIENCE & TECHNOLOGY - NTNU. Apply Today.
A critical challenge for microbiology and medicine is how to cure infections by bacteria that survive antibiotic treatment by persistence or tolerance. Seeking mechanisms behind such high survival, we developed a forward-genetic method for efficient isolation of high-survival mutants in any culturable bacterial species. We found that perturbation of an essential biosynthetic pathway (arginine biosynthesis) in a mycobacterium generated three distinct forms of resistance to diverse antibiotics, each mediated by induction of WhiB7: high persistence and tolerance to kanamycin, high survival upon exposure to rifampicin, and minimum inhibitory concentration–shifted resistance to clarithromycin. As little as one base change in a gene that encodes, a metabolic pathway component conferred multiple forms of resistance to multiple antibiotics with different targets. This extraordinary resilience may help explain how substerilizing exposure to one antibiotic in a regimen can induce resistance to
1Organisation Européenne pour la Recherche Nucléaire (CERN), Geneva, Switzerland
2Katholieke Universiteit (KU) Leuven, Institute for Nuclear and Radiation Physics, Leuven, Belgium
3Groupement d Intérêt Public ARRONAX, Nantes, France
4European Commission, Joint Research Centre, Nuclear Safety and Security, Karlsruhe, Germany
5National Physical Laboratory, Teddington, United Kingdom
6Johannes Gutenberg University, Mainz, Germany
7Pakistan Institute of Nuclear Science and Technology, Islamabad, Pakistan
8Institut Laue Langevin, Grenoble, France
9Paul Scherrer Institute, Villigen, Switzerland
The CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientific program of this unique installation a
Issued: Thu, 25 Feb 2021 14:42:00 GMT
Business School academics are working with industry leaders and partner universities to help boost innovation in Europe.
The €4.3m project will examine how different industries, companies, and cultures manage to adapt to rapidly changing situations.
It aims to help companies and technologists navigate how to communicate the value of new technology and have their ideas accepted in society, and for policy makers to better understand how to support and encourage innovation.
Professor Niall MacKenzie is leading the project at University of Glasgow Adam Smith Business School, working with Co-Investigators Dr Jillian Gordon and Dr Dominic Chalmers. He said: “Currently we don’t fully understand how society accepts new technologies or organisational forms in a way that is systematic and actionable. By investigating how society accepts new technologies, ideas, and ventures across 15 different topics our work will help unlock the innovation po
As oceans warm, large fish struggle
Warming ocean waters could reduce the ability of fish, especially large ones, to extract the oxygen they need from their environment. Animals require oxygen to generate energy for movement, growth and reproduction. In a recent paper in the
Proceedings of the National Academy of Science, an international team of researchers from McGill, Montana and Radboud universities describe their newly developed model to determine how water temperature, oxygen availability, body size and activity affect metabolic demand for oxygen in fish.
The model is based on physicochemical principles that look at oxygen consumption and diffusion at the gill surface in relation to water temperature and body size. Predictions were compared against actual measurements from over 200 fish species where oxygen consumption rates were measured at different water temperatures and across individuals of different body sizes.