How Inhibition of Enzyme Leads to the Development of Alzheimer s Analyzed by Angela Mohan on April 21, 2021 at 5:12 PM
Meprin β releases proteins from cell membranes, controlling important physiological functions in the human body. But, a dysregulation of this process can trigger the development of Alzheimer s and cancer.
Meprin β is regulated by fetuin-B binding to the enzyme when required, thereby preventing the release of other proteins, as per the findings in the journal Proceedings of the National Academy of Sciences .
Research team produced meprin β and fetuin-B in insect cells and then allowed them to react with one other in a test tube. Using enzyme kinetics and biophysical analyses, the researchers determined that this reaction resulted in an exceptionally stable, high-molecular-mass complex.