Tübingen Researcher Wins Worlds Largest Science Prize for Parkinsons miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
"Oscars® of Science" Awards $3 Million Prizes for Advances against Cancer, Cystic Fibrosis, Parkinson's Disease; Deep Insights into Quantum Field Theory and Differential Geometry SAN FRANCISCO, Sept. 14, 2023 /PRNewswire/ The Breakthrough Prize Foundation today announced the winners of the 2024 Breakthrough Prizes, honoring an esteemed group of the world's most brilliant minds for impactful scientific discoveries, including.
08 Apr 2021
A toxic brew of lysosomal lipids, reactive iron atoms, and oxidative stress can spell doom for human neurons. This is the upshot of the first-ever CRISPR screens at the genome-wide level in these cells. Researchers led by Martin Kampmann at the University of California, San Francisco, used the genome-editing tool to dial up or down expression of each protein-coding gene in the human neuronal genome. They uncovered a surprising connection between endolysosomal processing and the iron-dependent cell-death pathway called ferroptosis.
First genome-wide CRISPR screens in human neurons tweaks gene expression.
Endolyosomal function, oxidative stress, and iron homeostasis genes key to neuronal survival.