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Researchers from Skoltech and their colleagues have optimized data analysis for a common method of studying the 3D structure of DNA in single cells of a Drosophila fly. The new approach allows the scientists to peek with greater confidence into individual cells to study the unique ways DNA is packaged there and get closer to understanding this crucial process s underlying mechanisms. The paper was published in the journal
Nature Communications.
The reason a roughly two-meter-long strand of DNA fits into the tiny nucleus of a human cell is that chromatin, a complex of DNA and proteins, packages it into compact but very complex structures. To study the way DNA is packaged, researchers worldwide have developed so-called chromosome conformation capture (3C) techniques, the most efficient of which is called Hi-C. Hi-C essentially catalogs all interacting fragments of a DNA strand via high-throughput sequencing.
Wednesday, 13 January 2021, 7:22 am
Researchers from Skoltech and their colleagues have
optimized data analysis for a common method of studying the
3D structure of DNA in single cells of a
Drosophila
fly. The new approach allows the scientists to peek with
greater confidence into individual cells to study the unique
ways DNA is packaged there and get closer to understanding
this crucial process s underlying mechanisms. The paper was
published
in the journal
Nature Communications.
The
reason a roughly two-meter-long strand of DNA fits into the
tiny nucleus of a human cell is that chromatin, a complex of
DNA and proteins, packages it into compact but very complex