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Gene behind heart defects in Down syndrome id

Researchers at the Francis Crick Institute and UCL have identified a gene that causes heart defects in Down syndrome, a condition that results from an additional copy of chromosome 21. Reducing the overactivity of this gene partially reversed these defects in mice, setting the scene for potential future therapies for heart conditions in people with Down syndrome.

City ofUnited kingdomRifdat aoidiEva lana elolaVictor tybulewiczMethod of researchPostdoctoral project research scientistPrincipal laboratory research scientistTimes university of the yearUniversity college londonLondon global universityImperial college londonCancer research united kingdomResearch councilPerha pharmaceuticalsFrancis crick institute

Influx of water and salts propel immune cells through the body

Influx of water and salts propel immune cells through the body
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Victor tybulewiczNature communicationsKarolinska instituteGroup leaderImmune cell biology laboratoryDown syndrome laboratory

Influx of water and salts propel immune cells

Researchers at the Francis Crick Institute, working with Imperial College London, King’s College London and University of Cambridge, have shown that an influx of water and ions into immune cells allows them to migrate to where they’re needed in the body.  

United kingdomCity ofVictor tybulewiczUniversity college londonKarolinska instituteCancer research united kingdomUniversity of cambridgeImperial college londonKing college londonNature communicationsMethod of researchResearch councilFrancis crick instituteCollege londonGroup leaderImmune cell biology laboratory

Researchers show that an influx of water and salts propel immune cells through the body

Researchers show that an influx of water and salts propel immune cells through the body
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United kingdomCity ofVictor tybulewiczKing college londonUniversity of cambridgeFrancis crick instituteImperial college londonKarolinska instituteNature communicationsCollege londonGroup leaderImmune cell biology laboratoryDown syndrome laboratory

Study Shows Genetic Basis Of Facial Changes In Down Syndrome

They found that having a third copy of the gene Dyrk1a and at least three other genes was responsible for changes in development that result in ‘craniofacial dysmorphology’, which shows up as shortened back-to-front length and widened diameter of the

City ofUnited kingdomVictor tybulewiczGroup leader of the down syndrome laboratoryKing college londonUniversity of calgaryQueen square institute of neurologyProfessor victor tybulewicz the francis crick instituteResearchers at king college londonProfessor elizabeth fisherSquare instituteProfessor victor tybulewiczFrancis crick instituteProfessor jeremy greenCollege londonElizabeth fisher