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 E-Mail IMAGE: Elisabeth Hennes is searching for potential IDO1 inhibitors with the nerwly developed cell-based assay. view more  Credit: @MPI of Molecular Physiology Our immune system is very successful when it comes to warding off viruses and bacteria. It also recognizes cancer cells as potential enemies and fights them. However, cancer cells have developed strategies to evade surveillance by the immune system and to prevent immune response. In recent years, fighting cancer with the help of the immune system has entered into clinical practice and gained increasing importance as a therapeutical approach. Current therapies apply so-called immune checkpoint inhibitors. Immune checkpoints are located on the surface of cancer cells and slow down the immune response. Targeting these checkpoints can release this tumour-induced brake. Another strategy developed by cancer cells to escape the immune response is the production of the enzyme indoleamine-2,3-dioxygenase (IDO1), w

Slava zieglerElisabeth hennesHerbert waldmannDifferent mechanismsCell biologyMolecular biologyPharmaceutical sciencesஹெர்பர்ட் வால்ட்மேன்உயிர் வேதியியல்செல் உயிரியல்மூலக்கூறு உயிரியல்மருந்து அறிவியல்