Bekannte Wirkstoffe zeigen unerwartete Wirkung bionity.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bionity.com Daily Mail and Mail on Sunday newspapers.
Researchers identify an unexpected effect for already characterized active substances
Every innovative drug starts with the search for an active substance targeting key players in disease-related processes. However, there is no perfect drug that affects the one target in the body: no effect without side effects, as also described in most medicine information leaflets. A group of chemists and biologists led by Prof. Herbert Waldmann and Dr. Slava Ziegler at the Max Planck Institute of Molecular Physiology in Dortmund have now combined different strategies to find bioactive molecules and identified an unexpected effect for a group of already characterized active substances: they all modulate cholesterol metabolism, a home-made problem, as it seems.
Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.
Eggs and embryos go through a more dynamic and complex journey than previously thought
The journey of the egg and the embryo through the fallopian tube or oviduct toward the uterus is not well understood, mainly because it is inaccessible for direct imaging.
Looking to shed new light on the dynamics of the eggs prior to fertilization and embryo transport preceding implantation, researchers at Baylor College of Medicine and Stevens Institute of Technology developed a novel imaging approach that has allowed them to see eggs and embryos as they move along the fallopian tube in a live animal.
Published in the journal
Splicing Dysfunction Identified in Usher Syndrome genengnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from genengnews.com Daily Mail and Mail on Sunday newspapers.