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A comprehensive approach that examines the intersection of multiple biological processes is necessary to elucidate the development of stress-related disorders. In a new study, investigators from McLean Hospital, a member of the Mass General Brigham health care system, working with colleagues at The University of Texas at Austin and Lieber Institute for Brain Development, uncovered both shared and distinct molecular changes across brain regions, genomic layers, cell types, and blood in individuals with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD).

United statesKerry resslerCharlesb nemeroffNikolaosp daskalakisJoel kleinmanClinical sciencesDivision of depressionHarvard medical schoolDepartment of psychiatryLieber institute for brain developmentNeurobiology of fear laboratory at mclean hospitalUniversity of texas at austinTranslational bioinformatics laboratory at mclean hospitalDell medical schoolLieber institute brain repositoryBehavioral sciences at dell medical school