Unresolved obstructive sleep apnoea (OSA) after an adenotonsillectomy, henceforth
referred to as persistent OSA, is increasingly recognised in children (2–18 years).
Although associated with obesity, underlying medical complexity, and craniofacial
disorders, persistent OSA also occurs in otherwise healthy children. Inadequate treatment
of persistent OSA can lead to long-term adverse health outcomes beyond childhood.
Positive airway pressure, used as a one-size-fits-all primary management strategy
for persistent childhood OSA, is highly efficacious but has unacceptably low adherence
rates.
Although phase 2 data suggested baricitinib as a potential treatment for patients
with SLE, which was supported in SLE-BRAVE-I, this result was not replicated in SLE-BRAVE-II.
No new safety signals were observed.
The common cold is responsible for 150 million missed workdays annually in the United States. Many of us will head to the nutrition supplement aisle to ward off these nasty viruses, but do these supp…
Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue
disease. Once considered an untreatable and unpredictable condition, research advancements
have improved our understanding of its disease pathogenesis and clinical phenotypes
and expanded our treatment armamentarium. Early and accurate diagnosis is essential,
while ongoing efforts to risk stratify patients have a central role in predicting
both organ involvement and disease progression. A holistic approach is required when
choosing the optimal therapeutic strategy, balancing the side-effect profile with
efficacy and tailoring the treatment according to the goals of care of the patient.