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Conservative oxygenation improves outcomes in critically ill children on invasive ventilation

1. Duration of organ support or death at 30 days was lower in the conservative oxygenation group compared to the liberal oxygenation group. 2. Prespecified adverse events were also lower in the conservative oxygenation group. Evidence Rating Level: 1 (Excellent) Study Rundown: The optimal systemic oxygenation target for critically ill children remains uncertain, with liberal

High-dose corticosteroids increase morbidity and mortality among hypoxic COVID-19 patients

1. Patients in the high-dose dexamethasone group reported significantly greater mortality within 28 days of treatment. 2. Occurrence of non-COVID-19 pneumonia and hyperglycemia was more frequent in the high-dose dexamethasone group compared to usual care. Evidence Rating Level: 1 (Excellent) Study Rundown: Low-dose corticosteroids has been shown to have clinical benefit among patients with COVID-19

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