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 E-Mail IMAGE: CRISPR-sciATAC is a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. The new method harnesses the programmability of the gene editing system. view more  Credit: Sanjana Lab of New York Genome Center and NYU NEW YORK, NY (April 29, 2021) - In a new resource for the scientific community, published today in Nature Biotechnology, researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center (NYGC) and New York University (NYU) developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. With this technology, they profile changes in genome organization and create a large-scale atlas of how loss of individual chromatin-altering enzymes impacts the human genome. The new method harnesses the programmability of the gene editing system CRISP

New yorkUnited statesMemorial sloan kettering cancer centerRockefeller universityNew york universityCold spring harbor laboratoryHospital for special surgeryAmerican museum of natural historyColumbia universityNeville sanjanaNoa liscovitch brauerKaren zipernJay shendureSanjana labYork genome centerRutgers cancer institute of new jersey