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Novel tool can add or remove sugar from proteins Sugar has been called evil, toxic, and poison. But the body needs sugars, too. Sugar molecules help cells recognize and fight viruses and bacteria, shuttle proteins from cell to cell, and make sure those proteins function. Too much or too little can contribute to a range of maladies, including neurodegenerative diseases like Alzheimer s, inflammation, diabetes, and even cancer. About 85 percent of proteins, including those associated with Alzheimer s and Parkinson s, are beyond the reach of current drugs. One critical and abundant sugar (O-GlcNAc, pronounced o-glick-nack) is found on over 5,000 proteins, often those considered undruggable.

Daniel ramirezEmily hendersonHarvard universitySchool of artsNature chemical biologyGraduate schoolChristina wooStudy first authorPostdoctoral scholarNeurodegenerative diseasesடேனியல் ரெமிரெஸ்எமிலி ஹென்டர்சன்ஹார்வர்ட் பல்கலைக்கழகம்பள்ளி ஆஃப் கலைகள்இயற்கை இரசாயன உயிரியல்பட்டதாரி பள்ளி