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Pushing T cells down memory lane may improve cancer therapy

/PRNewswire/ Scientists at St. Jude Children s Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR.

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Pushing T cells down memory lane may improve cancer therapy

Scientists at St. Jude Children s Research Hospital identified proteins that help decide T cell fate and used the finding to improve CAR-T cell th.

Doug greenHongbo chiJasont yusteinShondram pruett millerHongling huangCharles wm robertsSwantje liedmannDalia haydarGiedre krenciuteZhexin zhuZhao shiJonp connellyChristopher derenzoPiyush sharmaMarkj chenMao yang

Strategy overcomes EZH2 inhibitor resistance in SMARCB1 mutated cancer

Strategy overcomes EZH2 inhibitor resistance in SMARCB1 mutated cancer
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Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children.

Yiannis drososTaosheng chenEmma beaneMargaret larsenEmily hendersonSanthosh upadhyayaNatarajan bhanuCharles wm robertsSandi radko juettnerJacquelyn myersBaranda hansenSandeep dhandaRobert mobleyJanet partridgeXiaotu maBenjamin garcia