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Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

United statesBaylor college of medicineJun liWei liXing fangLingyong liZeinab mehseinChangqun yaoKimberley toliasNational institutes of healthDepartment of anesthesiologyMission connectDepartment of neurobiologyMarnixe heersink school of medicineUniversity of alabama at birminghamBaylor college

Morphine tolerance results from Tiam1-mediated maladaptive plasticity in spinal neurons

Understanding the mechanisms underlying tolerance and hyperalgesia is essential to enhance morphine’s utility in chronic pain management. Understanding the mechanisms underlying tolerance and hyperalgesia is essential to.

United statesBaylor college of medicineKimberley toliasJun liWei liXing fangLexi coonliChangqun yaoLingyong liZeinab mehseinNational institutes of healthMission connectDepartment of neurobiologyUniversity of alabama at birminghamMarnixe heersink school of medicineDepartment of anesthesiology

Morphine Tolerance Linked to Tiam1-Mediated Neuron Changes

Morphine Tolerance Linked to Tiam1-Mediated Neuron Changes
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United statesBaylor college of medicineChangqun yaoZeinab mehseinWei liJun liXing fangKimberley toliasLingyong liUniversity of alabama at birminghamMission connectDepartment of anesthesiologyDepartment of neurobiologyNational institutes of healthMarnixe heersink school of medicineBaylor college

Morphine tolerance found to result from Tiam1-mediated maladaptive plasticity in spinal neurons

Morphine tolerance found to result from Tiam1-mediated maladaptive plasticity in spinal neurons
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United statesBaylor college of medicineChangqun yaoLingyong liKimberley toliasDepartment of anesthesiologyUniversity of alabama at birminghamPublic domainBaylor collegeClinical investigationstudyClinical investigation

Gene Tiam1 Drives Onset of Chronic Neuropathic Pain

Gene Tiam1 Drives Onset of Chronic Neuropathic Pain
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United statesBaylor college of medicineXing fangLingyong liChangqun yaoGuanxing chenKimberleyf toliasYungang luJianghan universityDepartment of defenseUniversity of texas md anderson cancer centerUniversity of alabama at birminghamUniversity of alabamaNational institutes of healthMission connectBaylor college