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Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

Morphine tolerance results from Tiam1-mediated maladaptive plasticity in spinal neurons

Understanding the mechanisms underlying tolerance and hyperalgesia is essential to enhance morphine’s utility in chronic pain management. Understanding the mechanisms underlying tolerance and hyperalgesia is essential to.

Morphine Tolerance Linked to Tiam1-Mediated Neuron Changes

Morphine Tolerance Linked to Tiam1-Mediated Neuron Changes
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Morphine tolerance found to result from Tiam1-mediated maladaptive plasticity in spinal neurons

Morphine tolerance found to result from Tiam1-mediated maladaptive plasticity in spinal neurons
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