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Panbela Announces Publication of Preclinical and Clinical Data Titled: Inhibition of Polyamine Biosynthesis Preserves ß Cell Function in Type 1 Diabetes

Panbela Announces Publication of Preclinical and Clinical Data Titled: Inhibition of Polyamine Biosynthesis Preserves ß Cell Function in Type 1 Diabetes
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Study provides preliminary evidence in favor of a new type 1 diabetes treatment

Study provides preliminary evidence in favor of a new type 1 diabetes treatment
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Existing drug could be repurposed to treat type 1 diabetes, study suggests

Type 1 diabetes is an autoimmune disease that causes the body's immune system to attack and destroy insulin-producing beta cells in the pancreas. Traditional management of type 1 diabetes has primarily involved replacing the missing insulin with injections which, though effective, can be expensive and burdensome.

Breakthrough drug helps children with new-onset type 1 diabetes: Phase 3 trial

Breakthrough drug helps children with new-onset type 1 diabetes: Phase 3 trial
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PROTECT: Teplizumab Preserves Beta-Cell Function in Newly Diagnosed Type 1 Diabetes

In the PROTECT trial, teplizumab preserved β-cell function in newly diagnosed type 1 diabetes patients, slowing the decline of C-peptide levels, but key secondary endpoints, such as time in range and HbA1c, showed numerical trends without statistical significance.

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