G), invasion rate (
H,
I) in vitro model of LNCap cell. p 0.01 compared with negative group, #p 0.01 compared with down-regulation of RAMS11 group.
Abbreviations: Negative, negative mimics group; SiRAMS11, down-regulation of RAMS11 group; Top2α, over-expression of Top2α group.
Discussion
The treatment of prostate cancer is mainly determined by objective factors, including patient age, physical condition, clinical stage, Gleason score, presence or absence of pelvic lymph nodes, distant metastases, and life expectancy.
18 At present, there are various therapeutic methods for prostate cancer, each with advantages and disadvantages.
19 Comprehensive consideration should be given towards patients with early-stage prostate cancer according to the patient’s condition. While patients with advanced prostate cancer still cannot be cured, the treatment should aim to relieve clinical symptoms and to prolong survival.
31 Jan 2021 - 10:05
The Peninsula
Services Offered by SHCs
School Health Centers will allow school children to find more comfortable access to comprehensive medical services provided by the multidisciplinary team of physicians, nurses, dentists, dental hygienists, dental assistants, pharmacists, laboratory technicians, social counselors, dietary counselors, researchers, and other professionals.
The SHCs can be established in three geographical locations, which entail North, Central, and West of Qatar. The SHC will aim to cater to school children’s needs of several public and private schools in each area. Following the introduction or establishment of SHCs, parents may consent for their children to be assessed and treated during school hours. Parents may also book an appointment with the SHCs and accompany their children.
18 Previously, miR-183 has also been determined in the initiation and progression of osteosarcoma;
19–22 nevertheless, the prognostic and biological roles of miR‐183-5p in osteosarcoma remain unclear.
In this study, we explored the prognostic and biological functions of miR-183-5p in the progression of osteosarcoma. We revealed that miR-183-5p was upregulated in human primary osteosarcoma tissues and cell lines, and that high expression of miR-183-5p was associated with unfavorable prognosis in osteosarcoma patients. In addition, miR-183-5p was found to play a role in promoting osteosarcoma cell proliferation, migration and invasion in vitro.
Materials and Methods
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1
1Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, People’s Republic of China;
2Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, Liaoning, People’s Republic of China
Correspondence: Rui Ma
Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, People’s Republic of China
Background: Lung cancer is one of the most aggressive tumors with high incidence and mortality, which could be classified into lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD). Overexpression of Plakophilin-2 (PKP2) has been reported in multiple malignancies. However, the expression and function mechanism of PKP2 in LUAD remain illusive.