More than a third of lung cancers that progressed on osimertinib (Tagrisso) responded to combined targeting of
EGFR, a subgroup analysis of an early clinical trial showed.
Results in 45 patients showed one complete response and 12 partial responses to the bispecific antibody amivantamab (Rybrevant) targeting
EGFR and
MET and the third-generation EGFR tyrosine kinase inhibitor (TKI) lazertinib. An additional 16 patients had stable disease, resulting in a clinical benefit rate of 64%. A majority of responses lasted 6 months or longer. The overall response rate increased to 47% in patients with
EGFR/MET-based resistance.
Biomarker analysis yielded mixed results with next generation sequencing (NGS), but immunohistochemistry (IHC) identified a higher proportion of responding patients, reported Byoung Chul Cho, MD, of Yonsei Cancer Center in Seoul, at the American Society of Clinical Oncology (ASCO) virtual meeting.
Findings to be presented at the ASCO Annual Meeting show preliminary efficacy in patients with EGFR-mutated NSCLC and Janssen's commitment to address the need for new targeted therapies for this patient
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