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Risk Factors of Experiencing Side Effects of Cancer Treatment by Angela Mohan on April 7, 2021 at 12:08 PM
Psycho-Oncology, which includes 24 studies.
Steroids are essential for treating children with acute lymphoblastic leukemia, a type of cancer of the blood and bone marrow, but they can cause severe side effects such as psychological reactions and sleep problems.
However, evidence suggests that the type and dose of steroids are not related to psychological reactions, but may be related to sleep problems. Younger patients seem at risk for behavioral problems and older patients for sleep problems. There is a lot to gain in the prevention and treatment of steroid-induced psychological and sleep problems, and recognition comes first, said senior author Raphaële R.L. van Litsenburg, MD, PhD, of the Princess Máxima Center in The Netherlands. A standardized registration of these side effects and their risk factors is warranted for future studies.
Antibodies Deplete Cancer Cells in Mice and Human Cell Lines by Angela Mohan on March 2, 2021 at 12:14 PM
Science,
Science Immunology.
Some immunotherapy approaches against cancers rely on common cancer-related mutations to serve as antigens; they instigate an immune response to the cancer.
Although it is one of the most common mutant tumor suppressor genes known in human cancers, the cancer-related p53 tumor suppressor gene has not been successfully targeted via this approach.
In
Science, Emily Han-Chung Hsiue and colleagues successfully engineered a bispecific antibody to reactivate p53. Hsiue et al. first identified a distinct targetable fragment of the mutant tumor suppressor protein and characterized the structural basis for how the fragment is presented to T cells.
Role of Biomarkers In Assessing Renal Injury in Cancer Patients by Angela Mohan on February 4, 2021 at 11:03 AM
Kidney International Reports. Immune checkpoint inhibitors have improved the prognosis for patients with a wide range of malignancies including melanoma, non-small cell lung cancer and renal cancer, says Sandra Herrmann, M.D., a Mayo Clinic nephrologist and the study s senior author. In some patients, this enhanced immune response may target kidney tissue, leading to acute kidney inflammation known as interstitial nephritis.
Dr. Herrmann says a kidney biopsy is the gold standard to diagnose this condition. However, a kidney biopsy is an invasive procedure that some patients may not be able to undergo because of the risk of bleeding.
Over 56% Cancer Survivors Associated With Severe Covid-19 Illness by Hannah Joy on February 3, 2021 at 8:12 PM
In the United States, more than half (56.4%) of cancer survivors have additional underlying medical conditions associated with severe COVID-19 illness.
The report appearing in JNCI: The Journal of the National Cancer Institute, suggests that prevalence of these conditions among cancer survivors is nearly 40% higher than that in the general population.
Cancer, and other underlying medical conditions, including chronic obstructive pulmonary disease, heart diseases, diabetes, chronic kidney disease, and obesity, are associated with increased risk of severe COVID-19 illness.
For this study, investigators Changchuan (Charles) Jiang, MD, PhD, Roswell Park Comprehensive Cancer Center, Xuesong Han, PhD, American Cancer Society, and colleagues used data from the 2016-2018 National Health Interview Survey (NHIS), a national cross-sectional survey of the ci