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#VisualAbstract: Pembrolizumab and chemotherapy combination improves survival in advanced pleural mesothelioma

1. Patients in the pembrolizumab plus chemotherapy group reported a significantly greater overall survival compared to those in the chemotherapy alone group (17.3 months vs. 16.1 months). 2. Grade 5 adverse events were comparable in both groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Pleural mesothelioma often presents at an advanced stage, and platinum–pemetrexed chemotherapy is a

Perioperative pembrolizumabMinute medicine incEastern cooperative oncology groupRating levelEarly stage nonSmall cell lungBetween janLung cancerMalignant pleural mesotheliomaMedical oncology

Pembrolizumab and chemotherapy combination improves survival in advanced pleural mesothelioma

1. Patients in the pembrolizumab plus chemotherapy group reported a significantly greater overall survival compared to those in the chemotherapy alone group (17.3 months vs. 16.1 months). 2. Grade 5 adverse events were comparable in both groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Pleural mesothelioma often presents at an advanced stage, and platinum–pemetrexed chemotherapy

Perioperative pembrolizumabEastern cooperative oncology groupRating levelEarly stage nonSmall cell lungBetween janLung cancerMalignant pleural mesotheliomaMedical oncologyChronic disease

Afghanistan: Infectious Disease Outbreaks - Epidemiological week #02, 2024 (07 - 13 Jan 2024)) Situation Report #02 - Afghanistan

Afghanistan: Infectious Disease Outbreaks - Epidemiological week #02, 2024 (07 - 13 Jan 2024)) Situation Report #02 - Afghanistan
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Acute respiratory infectionBetween jan

Discontinuing oxytocin during active labour has no significant impact on neonatal morbidity

1. Neonatal morbidity rate was comparable between the continuous oxytocin and discontinuous oxytocin groups. 2. There was no significant difference in adverse events between both groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Oxytocin is known for reducing labour duration but may pose risks for neonatal morbidity. In the multicenter STOPOXY trial, participants receiving oxytocin

Rating levelHeat stable carbetocinPrevent hemorrhageBetween janContinued oxytocinInduction of labourNeonatal morbidityNeonatal mortalityOxytocin discontinuationChronic disease

High-dose oral semaglutide effectively glycemic control in patients with type 2 diabetes mellitus

1. HbA1c reduction was dose-dependent in the semaglutide group with the greatest change among patients on semaglutide 50 mg. 2. Higher doses of semaglutide were associated with more gastrointestinal symptoms. Evidence Rating Level: 1 (Excellent) Study Rundown: Maintaining glycemic control is an important goal for patients with type 2 diabetes. Currently, GLP-1 agonists, such as

Rating levelCardiovascular outcomesBetween janDiabetes mellitusGlp 1 agonistGlp 1 receptor agonistGlycemic controlType 2 diabetesType 2 diabetes mellitusChronic disease