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Ticagrelor monotherapy reduces bleeding risk following percutaneous coronary intervention

1. Clinically relevant bleeding was significantly lower with ticagrelor monotherapy than in the ticagrelor plus aspirin group. 2. Major cardiovascular and cerebrovascular events were comparable in both groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Dual antiplatelet therapy (DAPT) is the current standard of care for acute coronary syndrome (ACS) following percutaneous coronary intervention (PCI).

Intravascular ultrasound-guided stent insertion improves outcomes in patients with acute coronary syndrome

1. Target-vessel failure was significantly lower in the ultrasound-guided group than the angiography-guided group. 2. There was no significant difference between groups concerning stent thrombosis. Evidence Rating Level: 1 (Excellent) Study Rundown: Angiography-guided percutaneous coronary intervention (PCI) is the current standard of care for patients with coronary artery stenosis, although this is associated with complications.

#VisualAbstract: Hepatitis E vaccine shows promising 10-year efficacy in the Chinese population

1. Overall vaccine efficacy ranged from 83.1% to 86.6% during the 10-year period. 2. Detectable concentrations of antibodies persisted at the 8.5-year mark in Qindong. Evidence Rating Level: 1 (Excellent) Study Rundown: Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis worldwide. Currently, two recombinant HEV vaccines exist; however, little is known

High dose aflibercept may be promising for treatment of age-related macular degeneration

1. Aflibercept 8 mg was non-inferior to 2 mg for best-corrected visual acuity at 48 weeks. 2. Ocular adverse events were comparable across treatment groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Neovascular age-related macular degeneration (nAMD) is a major cause of vision loss worldwide. Anti-vascular endothelial growth factors, such as aflibercept, may improve treatment

Hepatitis E vaccine shows promising 10-year efficacy in the Chinese population

1. Overall vaccine efficacy ranged from 83.1% to 86.6% during the 10-year period. 2. Detectable concentrations of antibodies persisted at the 8.5-year mark in Qindong. Evidence Rating Level: 1 (Excellent) Study Rundown: Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis worldwide. Currently, two recombinant HEV vaccines exist; however, little is known

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