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Duke-NUS scientists develop new technique to reveal the hidden genome

Duke-NUS scientists develop new technique to reveal the hidden genome
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United kingdomSonia chothaniPatrick caseyOwen rackhamDean of research atMetabolic disordersMolecular cellAssistant professor owen rackhamSenior vice dean

Scientists Develop New Technique to Reveal the Hidden Genome

Thousands of short RNA sequences that code for microproteins and peptides have been identified

United kingdomSonia chothaniPatrick caseyOwen rackhamDean of research atScientists develop new techniqueMetabolic disordersMolecular cellAssistant professor owen rackhamSenior vice dean

New Technique for Revealing the Hidden Genome | Technology Networks

Using an innovative new technique, scientists at Duke-NUS Medical School and their collaborators have identified thousands of previously unknown DNA sequences in the human genome that code for microproteins and peptides potentially critical to human health and disease.

United kingdomSonia chothaniOwen rackhamMetabolic disordersMolecular cellAssistant professor owen rackham

Researchers develop a novel method to unveil hidden genome

Thousands of short RNA sequences that code for microproteins and peptides have been identified, opening new avenues for disease research and drug development.

United kingdomSonia chothaniPatrick caseyOwen rackhamDean of research atMetabolic disordersMolecular cellAssistant professor owen rackhamSenior vice deanEws india

Researchers discover molecule that provides dual protection against vascular inflammation

Researchers discover molecule that provides dual protection against vascular inflammation A multidisciplinary team of researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research (A STAR) in Singapore discovered a new mitochondrial peptide called MOCCI that plays an important role in regulating inflammation of blood vessel and immunity. The study, published in the journal Nature Communications, revealed how one gene encoded two molecules that provide two-pronged protection following viral infection. Chronic and excessive inflammation of the blood vessels, known as vascular inflammation, can lead to tissue damage and cardiovascular diseases such as atherosclerosis and fibrosis. Although some therapies have shown promising results in clinical trials, they have considerable side effects, such as immunosuppression leading to increased risk of infection, and limited efficacy. Therefore, more effective treatments are urgently needed.

Patrick caseyEmily hendersonOwen rackhamAgency for scienceMetabolic diseases programme atNature communicationsInstitute of molecularDean for research atSenior research fellow dr cheryl leeMetabolic diseases programmeAssociate professor ashley st johnAssistant professor owen rackhamSenior research fellow dr cherylCell biologyAssoc prof st johnAsst prof

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