Specifically, high white-matter hyperintensity volume in the splenium of the corpus callosum appears to be a particular manifestation of Alzheimer s disease, wrote a team led by Dr. Antoine Garnier-Crussard of Normandie University s Blood and Brain Institute in Caen, France. Our findings in a group of [beta amyloid-positive] Alzheimer s disease patients compared to [beta amyloid-negative] controls matched for the main vascular risk factors highlight the clinical relevance of posterior white-matter hyperintensities, and particularly [those] in the splenium of the corpus callosum, the group wrote. Splenium of the corpus callosum white-matter hyperintensities are the most strongly associated with cognitive performance in Alzheimer s disease, independently from [beta-amyloid] burden and gray-matter loss.