Specifically, high white-matter hyperintensity volume in the splenium of the corpus callosum appears to be a particular manifestation of Alzheimer's disease, wrote a team led by Dr. Antoine Garnier-Crussard of Normandie University's Blood and Brain Institute in Caen, France.
"Our findings in a group of [beta amyloid-positive] Alzheimer's disease patients compared to [beta amyloid-negative] controls matched for the main vascular risk factors highlight the clinical relevance of posterior white-matter hyperintensities, and particularly [those] in the splenium of the corpus callosum," the group wrote. "Splenium of the corpus callosum white-matter hyperintensities are the most strongly associated with cognitive performance in Alzheimer's disease, independently from [beta-amyloid] burden and gray-matter loss."