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Last modified on Sun 14 Mar 2021 05.33 EDT Sleep well. Take time out to relax. Connect with your friends and family. Such things would be advisable at any time – but might it be especially important in the coming months. According to a growing body of evidence, our psychological state can shape the immune system’s reaction to a new vaccine – including the development of protective antibodies that will help us to fend off infection. We already know that physical factors, such as the body mass index, can have an immediate effect on vaccine efficacy. In late February, for instance, a study of Italian healthcare workers found that obesity blunted the antibody response to the Pfizer/BioNTech jab. But based on our understanding of various vaccines for other diseases, it seems clear that our mental health and overall stress levels will also play an important role. “There’s quite a spectrum of opinion as to what things may help or harm the immune system,” says Prof Daniel Davis

United kingdomCity ofDaniel davisAnna whittakerSuzanne segerstromKavita vedharaDanny altmannImperial college londonUniversity of pittsburghUniversity of nottinghamUniversity of stirlingUniversity of manchesterUniversity of kentuckyProf daniel davisProf janice kiecolt glaserOhio state university college