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Researchers identify the mutations that drive resistance to PI3K inhibitors in breast cancer, find they can be overcome

Researchers identify the mutations that drive resistance to PI3K inhibitors in breast cancer, find they can be overcome
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United statesDejan juricBryan corcoranAndreas varkarisTermeer centerCancer centerGastrointestinal cancer centerTherapies investigational cancer therapeutics programCancer discoveryMass general cancer centerMass general brighamFerran fece de la cruzMass general cancerTargeted therapyTargeted therapiesInvestigational cancer therapeutics program

TransCode Therapeutics Announces Preliminary Clinical Results in First Patient in Phase 0 Clinical Study with Lead Therapeutic Candidate, TTX-MC138

TransCode Therapeutics Announces Preliminary Clinical Results in First Patient in Phase 0 Clinical Study with Lead Therapeutic Candidate, TTX-MC138
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United statesZdravka medarovaAndreas varkarisMichael dudleyAlan freidmanTranscode therapeutics incExchange commissionTermeer centerFirst patientLead therapeutic candidateCode therapeuticsDrug metabolismChief technology officerChief executive officerTargeted therapiesMassachusetts general hospital

TransCode Therapeutics (RNAZ) Announces Preliminary Clinical Results in First Patient in Phase 0 Clinical Study with Lead Therapeutic Candidate, TTX-MC138

TransCode Therapeutics (RNAZ) Announces Preliminary Clinical Results in First Patient in Phase 0 Clinical Study with Lead Therapeutic Candidate, TTX-MC138
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United statesAndreas varkarisMichael dudleyZdravka medarovaTermeer centerTranscode therapeutics incTranscode therapeuticsDrug metabolismChief technology officerChief executive officerTargeted therapiesMassachusetts general hospital

Community and Cancer at Center of AFC Fourth Anniversary What was it like to be there? – Dielli

Community and Cancer at Center of AFC Fourth Anniversary What was it like to be there? – Dielli
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United statesBlue hill country clubNew yorkRoberta panaritiBrizida kociEnkela panceAgim aliajRafaela priftiAndreas varkarisAlbanab mihaliIrvin cepaZhenisa hysenajAlbana mihaliLorenc malellariHarvard cancer centerRobotic surgical center

RLY-2608 Shows Broad Therapeutic Potential in PIK3CA-Mutant Solid Tumors

RLY-2608 led to sustained target inhibition with minimal effect on glucose homeostasis, acceptable safety, and antitumor activity in patients with PIK3CA-mutant solid tumors, according to interim data from the dose-escalation portion of the first-in-human phase 1 ReDiscover trial.

United statesAndreas varkarisMassachusetts general hospitalFirst in human phase 1 rediscover trial2023 aacr annual meetingRly 2608Patients with pik3ca mutant solid tumors