MyJournals.org - Science - IJMS, Vol. 24, Pages 9409: Localized Cutaneous Nodular Amyloidosis in a Patient with Sjögren’s Syndrome (International Journal of Molecular Sciences)
The recombinant human antibody NI006 was safe for the treatment of transthyretin amyloid cardiomyopathy in a small phase 1 trial and may also reduce amyloid protein accumulation in the heart.
Transthyretin-related cardiac amyloidosis is a progressive disease characterized by the deposition of amyloid protein fibrils in the heart. Amyloid fibril deposition thickens and stiffens the heart walls, and the disease is also known as stiff-heart syndrome.
Fred Hutch experts evaluate and treat all types of amyloidosis. We guide you every step of the way, combining our deep clinical expertise with a commitment to meet your unique needs.
The investigational antisense agent eplontersen slows disease progression and im-proves quality of life in hereditary transthyretin-mediated amyloid polyneuropathy, final data from a phase 3 trial indicate.