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Provenzano Lab, University of Minnesota Cancer cells (shown in green) often align their movement to collagen fibers (shown in white). Understanding how cells move is key to preventing cancer spread throughout the body. Tranquillo group, University of Minnesota Human skin cells entrapped in an aligned fibrin gel exhibit contact guidance by orienting themselves along the aligned protein fibers in tissues. Tranquillo group, University of Minnesota A University of Minnesota study provides the first proof of a 1982 theory that the mechanical resistance (the stiffness of the fibers) plays a key role in controlling the movement of cells. The discovery could have a major impact on regenerative medicine and cancer research.

United statesUniversity of california los angelesCity ofUnited kingdomVictork laiGreeshma thrivikramanConnie wangAlicja jagieAlexj levineSandral johnsonAlexander nelsonLos angelesRobert tranquilloBillianne schultzMark keatingElliotl botvinick