Cells Dispatch Repair Crews to Fix Faulty Protein Factories: Study
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Rare compound found in a shrub could help fight previously undruggable cancer protein
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IMAGE: Mingji Dai, professor of chemistry and a scientist at the Purdue University Center for Cancer Research, studied the compound found naturally in the roots of a shrub and discovered a. view more
Credit: Purdue University photo/Charles Jischke
A chemist from Purdue University has found a way to synthesize a compound to fight a previously undruggable cancer protein with benefits across a myriad of cancer types.
Inspired by a rare compound found in a shrub native to North America, Mingji Dai, professor of chemistry and a scientist at the Purdue University Center for Cancer Research, studied the compound and discovered a cost-effective and efficient way to synthesize it in the lab. The compound curcusone D has the potential to help combat a protein found in many cancers, including some forms of breast, brain, colorectal, prostate, lung and liver cancers, among others. The protein, dubbed BRAT1, had previously been deemed undruggable for its chemical p