Alessandro Gardini, a virtual product designer located in Brazil, also loves to play with automotive personal projects - including this Ram Rampage TRX idea
Gene Transcription Fine Tuned by New Checkpoint Mechanism
Alessandro Gardini, Ph.D., assistant professor in the Gene Expression & Regulation Program at The Wistar Institute, in his lab. [Wistar Institute]
May 18, 2021
Alessandro Gardini, Ph.D., assistant professor in the Gene Expression & Regulation Program at The Wistar Institute, in his lab. [Wistar Institute]
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Researchers from the Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, say they have discovered a new checkpoint mechanism that fine-tunes gene transcription.
Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII).
Credit: The Wistar Institute
PHILADELPHIA and MELBOURNE, Australia (May. 17, 2021) A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study published in
Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). Disruption of this mechanism leads to unrestricted gene transcription and is implicated in cancer.
The study points to new viable opportunities for therapeutic intervention demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies.
EGR1 Inhibits Pro-Inflammatory Gene Expression in Macrophages
January 14, 2021
Researchers at The Wistar Institute say they have discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. As part of their function to protect the body against pathogens, macrophages play a major role in initiation, maintenance, and resolution of inflammation.
The discovery expands the understanding of how macrophages are set off and deactivated in the inflammatory process, which is critical in many normal and pathological conditions, according to the scientists, who published their study “EGR1 is a gatekeeper of inflammatory enhancers in human macrophages” in