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Known as the Drug Lord in Rome, the prosecution requests 21 years in prison for Elvis Demçe

Known as the Drug Lord in Rome, the prosecution requests 21 years in prison for Elvis Demçe
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Mario palazziAlessandro corvesiFabrizio piscitelliAlessio marzaniFrancesco casciniDaniele gallarelloMatteo costacurtaLazio irriducibiliProsecutor office of romeElvis dem

Italian prince Matteo Costacurta accused of being Mafia hitman

Matteo Costacurta has been arrested after allegedly shooting and injuring a drug dealer in Rome

East sussexUnited kingdomMatteo costacurtaMarco francoAndrea fanelliElvis demceAlessio marzaniRoma polo clubWorld news

Polo-playing Italian aristocrat is charged with being a Mafia hitman

An Italian aristocrat, circled in red, has been charged with acting as a professional assassin accused of accepting a hit on another criminal. Alessandro Corvesi, left, is also among the accused.

Daniele gallarelloMatteo costacurtaAlessandro corvesiElvis demceAndrea fanelliAlessio marzaniPrince harryCommunity of st egidioRoma polo clubNuclei armati rivoluzionariBologna centraleSan camillo

Fundamental mechanism discovered that fine-tunes gene expression & is disrupted in cancer

Credit: The Wistar Institute PHILADELPHIA and MELBOURNE, Australia (May. 17, 2021) A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study published in Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). Disruption of this mechanism leads to unrestricted gene transcription and is implicated in cancer. The study points to new viable opportunities for therapeutic intervention demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies.

New yorkUnited statesDana farber cancer instituteNew south walesBenjamin blythOtto kaukoJenniferr devlinSaraha welshElisa barbieriKaylenej simpsonEdwind hawkinsMichael ohlmeyerDeboraha knightMatteo costacurtaStefan bjelosevicGareth gregory