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 E-Mail Researchers have mapped out the changes in metabolism that occur after a heart attack, publishing their findings today in the open-access eLife journal. Their study in mice reveals certain genes and metabolic processes that could aid or hinder recovery, and might be good targets for treatments to prevent damage after a heart attack. Although some studies have looked at how changes in individual body tissues underlie mechanisms of disease, the crosstalk between different tissues and their dysregulation has not been examined in heart attacks or other cardiovascular-related complications, explains first author Muhammad Arif, a PhD student at KTH Royal Institute of Technology, Stockholm, Sweden. In this study, we performed an integrated analysis of heart and other metabolically active tissues using a mouse model of heart attack and used systems biology approaches to get a systematic picture of the metabolic changes that occur.

United kingdomCity ofMuhammad arifEmily packerAdil mardinogluKing college londonAlice wallenberg foundationRoyal institute of technologyMax planck societyHoward hughes medical instituteSystems biologyCollege londonMedia relations managerஒன்றுபட்டது கிஂக்டம்நகரம் ஆஃப்முஹம்மது ஆரிப்