Although the expanding applications of blockchain technologies have been widely explored in the IS literature, a noticeable gap exists in understanding information systems development methods (ISDMs) that facilitate the implementation of systems leveraging these technologies. A conceptual foundation that cohesively organizes an ISDM along with its facets associated with the development lifecycle for this class of systems is lacking. Applying a Design Science Research approach and borrowing ideas from method engineering, we describe a comprehensive framework for the development of blockchain systems. A series of qualitative in-depth applicability checks with domain experts and case studies lend credence to the core framework fragments. The evaluation results demonstrate the utility of the proposed framework as a conceptual anchor to simplify the understanding of the complex nature of developing blockchain systems and lead researchers to suggest future research agendas in their quests us