mRNA COVID-19 vaccination is immunogenic in the immunocompromised
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Research suggests patients who receive COVID-19 vaccines prior to a transplant and subsequent immunosuppression may be protected from the disease.
New research shows that vaccination against SARS-CoV-2 (the virus that causes COVID-19) in immunosuppressed individuals is immunogenic, though to a lesser extent than in the general population.
Two studies in thoracic organ transplantation published in the
Journal of Heart and Lung Transplantation (JHLT) provide the evidence for such a conclusion. Peled
et al. describes 77 vaccinated heart transplant recipients and Havlin
et al. (currently in review) presents 48 vaccinated lung transplant recipients.
Both studies assessed the immunogenicity of Pfizer and BioNTech’s messenger (m)RNA vaccine BNT162b2 mRNA (now marketed as Comirnaty
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ADDISON, Texas, May 13, 2021 /PRNewswire/ Evidence is emerging about the immunogenicity of vaccination to the SARS-CoV-2 virus in immune-suppressed individuals, including organ transplant recipients. The
Journal of Heart and Lung Transplantation (JHLT) presents two key studies in thoracic organ transplantation.
Peled et al describes 77 vaccinated heart transplant recipients, and Havlin et al presents 48 vaccinated lung transplant recipients. Both of these studies assessed the mRNA vaccine BNT162b2 mRNA (Pfizer/BioNTech). Vaccination was safe with no evidence of short-term allograft-related adverse effects in either cohort. The IgG vaccine-induced antibody response was lower in the transplant patients compared to that reported for the general population, especially in those heart and lung transplant recipients on anti-metabolite immune suppression that contained mycophenolic acid. Havlin et al specifically evaluated T- cell responses in lun
April is National Donate Life Month
Celebrating the lifesaving generosity of organ, eye and tissue donation
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National Donate Life Month (NDLM), an observance to focus national attention on the need and importance of organ, eye and tissue donation. National Donate Life Month is about the importance of registering your decision to be a donor, and honoring deceased and living donors - recognizing that the generosity of donors makes saving lives through transplantation possible.
2021 National Donate Life Month, Garden of Life artwork
National Donate Life Month (NDLM) focuses attention on the need and importance of organ, eye and tissue donation.