lose some effectiveness over time. you still believe that at some point the general public will need booster shots, just the fda advisory committee is not there yet? >> jake, what i believe -- and, again, this is my opinion as a scientist and a public health person -- that it is entirely conceivable, and maybe likely, that ultimately when we look back on this, the proper regimen for protection, optimal protection and durability of protection, would be more than just the prime and the boost followed by three to four weeks. that it might actually entail a third boost. that is entirely conceivable because, remember, jake, when we did the initial studies, what we did was we had to move very, very quickly because we were dealing, and still are, with an emergency situation. so the prime followed by a boost in three weeks for pfizer and four weeks for moderna has