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IMAGE: EGCG maintains neuronal cell cytoskeleton integrity. Methyl glyoxal treatment leads to glycation of actin and microtubules leading to hampered growth of neuritic extensions and microtubule organization. Microtubule stabilization by +TIP...
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Credit: Correspondence to - Subashchandrabose Chinnathambi - s.chinnathambi@ncl.res.in
Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network" which reported that the chemical modulators of Tau PTMs, such as kinase inhibitors and antibody-based therapeutics, have been developed, but natural compounds, as modulators of Tau PTMs are not much explored.
These authors applied biophysical and biochemical techniques like fluorescence kinetics, oligomerization analysis and transmission electron microscopy to investigate the impact of EGCG on Tau glycation