Cristian Benavente levelled proceedings for Antwerp in the 73rd minute after receiving a timely assist from Simen Kristiansen Jukleroed.
With 10 minutes left to full-time, the Democratic Republic of the Congo international Mbokani scored the winning goal.
The victory moved Ivan Leko’s men to the fourth spot on the league table after accruing 31 points from 19 games.
Mbokani featured for the duration of the game along with Seck while Ghana international Nana Ampomah made way for Koji Miyoshi in the 57th minute.
Burundi national team captain Saido Berahino was brought on for Lucas Ribeiro while Senegal international Modou Diagne played for 80 minutes before he was replaced by Joris Kayembe Ditu, but they could not help Charleroi avoid defeat.