Appointments for Sunday's clinic filled up fast as 750 people signed up to receive the vaccine.
Across the state, vaccines are being administered to people in Phase 1A and 1B, which includes health care workers, residents and staff at long-term health facilities, people who are 65 years or older and people who have at least one chronic medical condition.
Mayor Sylvester Turner announced that the Moderna vaccine was being administered at the city's site located at the Bayou City Event Center.
People without appointments were asked not to show up at the site because they will not be seen.
Most of Sunday's appointments were booked through the department's call center on Saturday, despite the high volume of calls it received, which forced officials to move to an on-site registration format.